CATH Domain 4v2kA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.760	Cytochrome Bc1 Complex; Chain D, domain 2
	1.10.760.10	Cytochrome c-like domain

Domain Context

CATH Clusters

Superfamily	Cytochrome c-like domain
Functional Family

Enzyme Information

1.8.2.2

Thiosulfate dehydrogenase.

based on mapping to UniProt D3RVD4

2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c.

-!- The enzyme catalyzes the reversible formation of a sulfur-sulfur bond between the sulfane atoms of two thiosulfate molecules, yielding tetrathionate and releasing two electrons. -!- In many bacterial species the enzyme is a diheme c-type cytochrome. -!- In a number of organisms, including Thiomonas intermedia and Sideroxydans lithotrophicus, a second diheme cytochrome (TsdB) acts as the electron acceptor. -!- However, some organisms, such as Allochromatium vinosum, lack TsdB. -!- The electron acceptor in these organisms may be the high-potential iron-sulfur protein (HiPIP).

UniProtKB Entries (1)

D3RVD4

TSDA_ALLVD

Allochromatium vinosum DSM 180

Thiosulfate dehydrogenase

PDB Structure

PDB	4V2K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanism of Thiosulfate Oxidation in the Soxa Family of Cysteine-Ligated Cytochromes Grabarczyk, D.B., Chappell, P.E., Eisel, B., Johnson, S., Lea, S.M., Berks, B.C. J.Biol.Chem.