CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.565 | Heat Shock Protein 90 |
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3.30.565.10 | Histidine kinase-like ATPase, C-terminal domain |
Domain Context
CATH Clusters
Superfamily | Histidine kinase-like ATPase, C-terminal domain |
Functional Family | Mitochondrial pyruvate dehydrogenase kinase isoform 2 |
Enzyme Information
2.7.11.2 |
[Pyruvate dehydrogenase (acetyl-transferring)] kinase.
based on mapping to UniProt Q15119
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.
-!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. -!- Phosphorylation inactivates EC 1.2.4.1. -!- Formerly EC 2.7.1.99.
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UniProtKB Entries (1)
Q15119 |
PDK2_HUMAN
Homo sapiens
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
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PDB Structure
PDB | 4V26 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells.
Oncotarget
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