CATH Domain 4uyhB00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.920	Histone Acetyltransferase; Chain A
	1.20.920.10	Bromodomain-like

Domain Context

CATH Clusters

Superfamily	Bromodomain-like
Functional Family	Bromodomain-containing protein 4

Enzyme Information

UniProtKB Entries (1)

BRD2_HUMAN

Homo sapiens

Bromodomain-containing protein 2

PDB Structure

PDB	4UYH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The Discovery of I-Bet726 (Gsk1324726A), a Potent Tetrahydroquinoline Apoa1 Up-Regulator and Selective Bet Bromodomain Inhibitor. Gosmini, R., Nguyen, V.L., Toum, J., Simon, C., Brusq, J.M., Krysa, G., Mirguet, O., Riou-Eymard, A.M., Boursier, E.V., Trottet, L., Bamborough, P., Clark, H., Chung, C.W., Cutler, L., Demont, E.H., Kaur, R., Lewis, A.J., Schilling, M.B., Soden, P.E., Taylor, S., Walker, A.L., Walker, M.D., Prinjha, R.K., Nicodeme, E. J.Med.Chem.