CATH Domain 4uxxA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.287	Helix Hairpins
	1.10.287.3610

Domain Context

CATH Clusters

Superfamily	1.10.287.3610
Functional Family	Diacylglycerol kinase

Enzyme Information

2.7.1.107

Diacylglycerol kinase (ATP).

based on mapping to UniProt P0ABN1

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

-!- Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. -!- Activity is stimulated by certain phospholipids. -!- In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger. -!- cf. EC 2.7.1.174.

UniProtKB Entries (1)

P0ABN1

KDGL_ECOLI

Escherichia coli K-12

Diacylglycerol kinase

PDB Structure

PDB	4UXX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Ternary Structure Reveals Mechanism of a Membrane Diacylglycerol Kinase. Li, D., Stansfeld, P.J., Sansom, M.S.P., Keogh, A., Vogeley, L., Howe, N., Lyons, J.A., Aragao, D., Fromme, P., Fromme, R., Basu, S., Grotjohann, I., Kupitz, C., Rendek, K., Weierstall, U., Zatsepin, N.A., Cherezov, V., Liu, W., Bandaru, S., English, N.J., Gati, C., Barty, A., Yefanov, O., Chapman, H.N., Diederichs, K., Messerschmidt, M., Boutet, S., Williams, G.J., Marvin Seibert, M., Caffrey, M. Nat.Commun.