CATH Domain 4uuqA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Monoglyceride lipase

Enzyme Information

3.1.1.23

Acylglycerol lipase.

based on mapping to UniProt Q99685

Hydrolyzes glycerol monoesters of long-chain fatty acids.

UniProtKB Entries (1)

MGLL_HUMAN

Homo sapiens

Monoglyceride lipase

PDB Structure

PDB	4UUQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Selective Blockade of the Hydrolysis of the Endocannabinoid 2-Arachidonoylglycerol Impairs Learning and Memory Performance While Producing Antinociceptive Activity in Rodents. Griebel, G., Pichat, P., Beeske, S., Leroy, T., Redon, N., Jacquet, A., Francon, D., Bert, L., Even, L., Lopez-Grancha, M., Tolstykh, T., Sun, F., Yu, Q., Brittain, S., Arlt, H., He, T., Zhang, B., Wiederschain, D., Bertrand, T., Houtmann, J., Rak, A., Vallee, F., Michot, N., Auge, F., Menet, V., Bergis, O.E., George, P., Avenet, P., Mikol, V., Didier, M., Escoubet, J. Sci.Rep.