CATH Domain 4ut2A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.21	Purple Acid Phosphatase; chain A, domain 2
	3.60.21.10	Metallo-dependent phosphatases

Domain Context

CATH Clusters

Superfamily	3.60.21.10
Functional Family	Serine/threonine-protein phosphatase

Enzyme Information

3.1.3.16

Protein-serine/threonine phosphatase.

based on mapping to UniProt P36873

[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.

-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

P36873

PP1G_HUMAN

Homo sapiens

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

PDB Structure

PDB	4UT2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Targeted Redox Inhibition of Protein Phosphatase 1 by Nox4 Regulates Eif2Alpha-Mediated Stress Signaling. Santos, C.X., Hafstad, A.D., Beretta, M., Zhang, M., Molenaar, C., Kopec, J., Fotinou, D., Murray, T.V., Cobb, A.M., Martin, D., Zeh Silva, M., Anilkumar, N., Schroder, K., Shanahan, C.M., Brewer, A.C., Brandes, R.P., Blanc, E., Parsons, M., Belousov, V., Cammack, R., Hider, R.C., Steiner, R.A., Shah, A.M. Embo J.