CATH Domain 4uhgA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.228	Phosphoenolpyruvate Carboxykinase; domain 3
	3.90.228.10

Domain Context

CATH Clusters

Superfamily	3.90.228.10
Functional Family	Poly [ADP-ribose] polymerase tankyrase-2

Enzyme Information

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt Q9H2K2

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt Q9H2K2

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

Q9H2K2

TNKS2_HUMAN

Homo sapiens

Poly [ADP-ribose] polymerase tankyrase-2

PDB Structure

PDB	4UHG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Nathubhai, A., Haikarainen, T., Hayward, P.C., Munoz-Descalzo, S., Thompson, A.S., Lloyd, M.D., Lehtio, L., Threadgill, M.D. Eur.J.Med.Chem.