CATH Domain 4ucxA02

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.480	Cytochrome-c3 Hydrogenase; Chain A, domain 2
	4.10.480.10	Cytochrome-c3 hydrogenase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Cytochrome-c3 hydrogenase, C-terminal domain
Functional Family

Enzyme Information

1.12.2.1

Cytochrome-c3 hydrogenase.

based on mapping to UniProt P18187

H(2) + 2 ferricytochrome c3 = 2 H(+) + 2 ferrocytochrome c3.

-!- Some forms of the enzyme contain nickel ([NiFe]-hydrogenases) and, of these, some contain selenocysteine ([NiFeSe]-hydrogenases). -!- Methylene blue and other acceptors can also be reduced.

UniProtKB Entries (1)

P18188

PHNL_DESFR

Desulfovibrio fructosivorans

Periplasmic [NiFe] hydrogenase large subunit

PDB Structure

PDB	4UCX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A threonine stabilizes the NiC and NiR catalytic intermediates of [NiFe]-hydrogenase. Abou-Hamdan, A., Ceccaldi, P., Lebrette, H., Gutierrez-Sanz, O., Richaud, P., Cournac, L., Guigliarelli, B., De Lacey, A.L., Leger, C., Volbeda, A., Burlat, B., Dementin, S. J. Biol. Chem.