CATH Domain 4u84A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.20	Single Sheet
	2.20.70	Ubiquitin Ligase Nedd4; Chain: W;
	2.20.70.10

Domain Context

CATH Clusters

Superfamily	2.20.70.10
Functional Family

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q13526

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q13526

PIN1_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

PDB Structure

PDB	4U84
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease. Chen, C.H., Li, W., Sultana, R., You, M.H., Kondo, A., Shahpasand, K., Kim, B.M., Luo, M.L., Nechama, M., Lin, Y.M., Yao, Y., Lee, T.H., Zhou, X.Z., Swomley, A.M., Allan Butterfield, D., Zhang, Y., Lu, K.P. Neurobiol.Dis.