CATH Domain 4u6rA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1

Enzyme Information

2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt O75460 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
3.1.26.-	Endoribonucleases producing 5'-phosphomonoesters. based on mapping to UniProt O75460

UniProtKB Entries (1)

ERN1_HUMAN

Homo sapiens

Serine/threonine-protein kinase/endoribonuclease IRE1

PDB Structure

PDB	4U6R
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Unfolded Protein Response in Cancer: IRE1 alpha Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability. Harrington, P.E., Biswas, K., Malwitz, D., Tasker, A.S., Mohr, C., Andrews, K.L., Dellamaggiore, K., Kendall, R., Beckmann, H., Jaeckel, P., Materna-Reichelt, S., Allen, J.R., Lipford, J.R. Acs Med.Chem.Lett.