CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.90 | Alpha-Beta Complex | |
3.90.226 | 2-enoyl-CoA Hydratase; Chain A, domain 1 | |
3.90.226.10 | 2-enoyl-CoA Hydratase; Chain A, domain 1 |
Domain Context
CATH Clusters
Superfamily | 2-enoyl-CoA Hydratase; Chain A, domain 1 |
Functional Family | ATP-dependent Clp protease proteolytic subunit |
Enzyme Information
3.4.21.92 |
Endopeptidase Clp.
based on mapping to UniProt P9WPC5
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.
|
UniProtKB Entries (1)
P9WPC5 |
CLPP1_MYCTU
Mycobacterium tuberculosis H37Rv
ATP-dependent Clp protease proteolytic subunit 1
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PDB Structure
PDB | 4U0G |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery.
Proc.Natl.Acad.Sci.USA
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