CATH Domain 4tthB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt Q00534

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (2)

Q01043	CGH2_SHV21 Herpesvirus saimiri (strain 11) Cyclin homolog
Q00534	CDK6_HUMAN Homo sapiens Cyclin-dependent kinase 6

PDB Structure

PDB	4TTH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. Li, Z., Wang, X., Eksterowicz, J., Gribble, M.W., Alba, G.Q., Ayres, M., Carlson, T.J., Chen, A., Chen, X., Cho, R., Connors, R.V., DeGraffenreid, M., Deignan, J.T., Duquette, J., Fan, P., Fisher, B., Fu, J., Huard, J.N., Kaizerman, J., Keegan, K.S., Li, C., Li, K., Li, Y., Liang, L., Liu, W., Lively, S.E., Lo, M.C., Ma, J., McMinn, D.L., Mihalic, J.T., Modi, K., Ngo, R., Pattabiraman, K., Piper, D.E., Queva, C., Ragains, M.L., Suchomel, J., Thibault, S., Walker, N., Wang, X., Wang, Z., Wanska, M., Wehn, P.M., Weidner, M.F., Zhang, A.J., Zhao, X., Kamb, A., Wickramasinghe, D., Dai, K., McGee, L.R., Medina, J.C. J.Med.Chem.