CATH Domain 4tr9A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family	Fructose-bisphosphate aldolase

Enzyme Information

4.1.2.13

Fructose-bisphosphate aldolase.

based on mapping to UniProt Q7KQL9

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

Q7KQL9

ALF_PLAF7

Plasmodium falciparum 3D7

Fructose-bisphosphate aldolase

PDB Structure

PDB	4TR9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex. Nemetski, S.M., Cardozo, T.J., Bosch, G., Weltzer, R., O'Malley, K., Ejigiri, I., Kumar, K.A., Buscaglia, C.A., Nussenzweig, V., Sinnis, P., Levitskaya, J., Bosch, J. Malar.J.