CATH Domain 4tosA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.228	Phosphoenolpyruvate Carboxykinase; domain 3
	3.90.228.10

Domain Context

CATH Clusters

Superfamily	3.90.228.10
Functional Family	Poly [ADP-ribose] polymerase tankyrase-2

Enzyme Information

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt O95271

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt O95271

UniProtKB Entries (1)

O95271

TNKS1_HUMAN

Homo sapiens

Poly [ADP-ribose] polymerase tankyrase-1

PDB Structure

PDB	4TOS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Kulak, O., Chen, H., Holohan, B., Wu, X., He, H., Borek, D., Otwinowski, Z., Yamaguchi, K., Garofalo, L.A., Ma, Z., Wright, W., Chen, C., Shay, J.W., Zhang, X., Lum, L. Mol.Cell.Biol.