CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.1410 | Poly(a)-polymerase, middle domain | |
1.10.1410.20 | 2'-5'-oligoadenylate synthetase 1, domain 2 |
Domain Context
CATH Clusters
Superfamily | 2'-5'-oligoadenylate synthetase 1, domain 2 |
Functional Family | 2'-5'-oligoadenylate synthetase 3 |
Enzyme Information
2.7.7.84 |
2'-5' oligoadenylate synthase.
based on mapping to UniProt Q9Y6K5
3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate.
-!- The enzyme is activated by binding to double-stranded RNA. -!- The resulting product binds to and activates RNase L, which subsequently degrades the RNA. -!- Oligoadenylates of chain lengths 2, 4 and 5 are also produced. -!- The dimer does not have any known biological activity.
|
UniProtKB Entries (1)
Q9Y6K5 |
OAS3_HUMAN
Homo sapiens
2'-5'-oligoadenylate synthase 3
|
PDB Structure
PDB | 4S3N |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3.
Proc.Natl.Acad.Sci.USA
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