CATH Domain 4rv7A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1700	YojJ-like (1
	3.40.1700.10	DNA integrity scanning protein, DisA, N-terminal domain

Domain Context

CATH Clusters

Superfamily	DNA integrity scanning protein, DisA, N-terminal domain
Functional Family	Diadenylate cyclase

Enzyme Information

2.7.7.85

Diadenylate cyclase.

based on mapping to UniProt Q8Y5E4

2 ATP = 2 diphosphate + cyclic di-3',5'-adenylate.

-!- Cyclic di-3',5'-adenylate is a bioactive molecule produced by some bacteria and archaea, which may function as a secondary signaling molecule. -!- The intracellular bacterial pathogen Listeria monocytogenes secretes it into the host's cytosol, where it triggers a cytosolic pathway of innate immunity.

UniProtKB Entries (1)

Q8Y5E4

DACA_LISMO

Listeria monocytogenes EGD-e

Diadenylate cyclase

PDB Structure

PDB	4RV7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and Biochemical Analysis of the Essential Diadenylate Cyclase CdaA from Listeria monocytogenes. Rosenberg, J., Dickmanns, A., Neumann, P., Gunka, K., Arens, J., Kaever, V., Stulke, J., Ficner, R., Commichau, F.M. J.Biol.Chem.