CATH Domain 4rt0A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.220	predicted glycosyltransferase like domains

Domain Context

CATH Clusters

Superfamily	predicted glycosyltransferase like domains
Functional Family

Enzyme Information

2.4.1.33

Mannuronan synthase.

based on mapping to UniProt Q9HY69

GDP-alpha-D-mannuronate + ((1->4)-beta-D-mannuronosyl)(n) = GDP + ((1->4)-beta-D-mannuronosyl)(n+1).

-!- The enzyme catalyzes the polymerization of beta-D-mannuronate residues into a mannuronan polymer, an intermediate in the biosynthesis of alginate. -!- It is found in brown algae and in alginate-producing bacterial species from the Pseudomonas and Azotobacter genera.

UniProtKB Entries (1)

Q9HY69

ALG44_PSEAE

Pseudomonas aeruginosa PAO1

Mannuronan synthase

PDB Structure

PDB	4RT0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Dimeric c-di-GMP Is Required for Post-translational Regulation of Alginate Production in Pseudomonas aeruginosa. Whitney, J.C., Whitfield, G.B., Marmont, L.S., Yip, P., Neculai, A.M., Lobsanov, Y.D., Robinson, H., Ohman, D.E., Howell, P.L. J.Biol.Chem.