CATH Domain 4rqeA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.930	BirA Bifunctional Protein; domain 2
	3.30.930.10	Bira Bifunctional Protein; Domain 2

Domain Context

CATH Clusters

Superfamily	Bira Bifunctional Protein; Domain 2
Functional Family	Serine--tRNA ligase, cytoplasmic

Enzyme Information

6.1.1.11

Serine--tRNA ligase.

based on mapping to UniProt P49591

(1) ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). (2) ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).

-!- This enzyme also recognizes tRNA(Sec), the special tRNA for selenocysteine, and catalyzes the formation of L-seryl-tRNA(Sec), the substrate for EC 2.9.1.1.

UniProtKB Entries (1)

P49591

SYSC_HUMAN

Homo sapiens

Serine--tRNA ligase, cytoplasmic

PDB Structure

PDB	4RQE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	SerRS-tRNA Sec complex structures reveal mechanism of the first step in selenocysteine biosynthesis Wang, C., Guo, Y., Tian, Q., Jia, Q., Gao, Y., Zhang, Q., Zhou, C., Xie, W. Nucleic Acids Res.