CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.50 | Alpha/alpha barrel |
|
1.50.10 | Glycosyltransferase |
|
1.50.10.130 | Terpene synthase, N-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Terpene synthase, N-terminal domain |
| Functional Family | Isoprene synthase, chloroplastic |
Enzyme Information
| 4.2.3.61 |
5-epiaristolochene synthase.
based on mapping to UniProt Q40577
(2E,6E)-farnesyl diphosphate = (+)-5-epiaristolochene + diphosphate.
-!- Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.
|
UniProtKB Entries (1)
| Q40577 |
5EAS_TOBAC
Nicotiana tabacum
5-epi-aristolochene synthase
|
PDB Structure
| PDB | 4RNQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.
Acs Chem.Biol.
|
