CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.10990 | GTP cyclohydrolase II |
Domain Context
CATH Clusters
| Superfamily | GTP cyclohydrolase II |
| Functional Family | Riboflavin biosynthesis protein RibBA |
Enzyme Information
| 3.5.4.25 |
GTP cyclohydrolase II.
based on mapping to UniProt O08315
GTP + 3 H(2)O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D- ribosylamino)pyrimidine + diphosphate.
-!- Two C-N bonds are hydrolyzed, releasing formate, with simultaneous removal of the terminal diphosphate.
|
UniProtKB Entries (1)
| O08315 |
RIBA_HELPY
Helicobacter pylori 26695
GTP cyclohydrolase-2
|
PDB Structure
| PDB | 4RL4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and biochemical characterization of GTP cyclohydrolase II from Helicobacter pylori reveals its redox dependent catalytic activity.
J.Struct.Biol.
|