CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1970 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1970 |
| Functional Family |
Enzyme Information
| 1.1.1.261 |
sn-glycerol-1-phosphate dehydrogenase.
based on mapping to UniProt Q58122
sn-glycerol 1-phosphate + NAD(P)(+) = glycerone phosphate + NAD(P)H.
-!- Responsible for the formation of archaea-specific sn-glycerol-1- phosphate, the first step in the biosynthesis of polar lipids in archaea. -!- It is the enantiomer of sn-glycerol 3-phosphate, the form of glycerophosphate found in bacteria and eukaryotes. -!- The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 2.5.1.41 and EC 2.5.1.42, which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 to form CDP- unsaturated archaeol. -!- The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine. -!- Activity of the enzyme is stimulated by K(+).
|
UniProtKB Entries (1)
| Q58122 |
G1PDH_METJA
Methanocaldococcus jannaschii DSM 2661
Glycerol-1-phosphate dehydrogenase [NAD(P)+]
|
PDB Structure
| PDB | 4RGV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and Evolution of the Archaeal Lipid Synthesis Enzyme sn-Glycerol-1-phosphate Dehydrogenase.
J.Biol.Chem.
|
