CATH Domain 4rezA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.8	Helicase, Ruva Protein; domain 3
	1.10.8.1190	Papain-like viral protease, thumb domain

Domain Context

CATH Clusters

Superfamily	1.10.8.1190
Functional Family	ORF1ab polyprotein

Enzyme Information

UniProtKB Entries (1)

M4STU1_9BETC

Human betacoronavirus 2c Jordan-N3/2012

ORF1ab protein

PDB Structure

PDB	4REZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression. Bailey-Elkin, B.A., Knaap, R.C., Johnson, G.G., Dalebout, T.J., Ninaber, D.K., van Kasteren, P.B., Bredenbeek, P.J., Snijder, E.J., Kikkert, M., Mark, B.L. J.Biol.Chem.