CATH Classification
Domain Context
CATH Clusters
| Superfamily | Calcium-transporting ATPase, cytoplasmic transduction domain A |
| Functional Family | Sodium/potassium-transporting ATPase subunit alpha |
Enzyme Information
| 7.2.2.13 |
Na(+)/K(+)-exchanging ATPase.
based on mapping to UniProt P05024
ATP + H(2)O + Na(+)(Side 1) + K(+)(Side 2) = ADP + phosphate + Na(+)(Side 2) + K(+)(Side 1).
-!- P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- An enzyme from the plasma membrane of animal cells that catalyzes the efflux of three Na(+) and influx of two K(+) per ATP hydrolyzed. -!- It is involved in generating the plasma membrane electrical potential. -!- Formerly EC 3.6.1.37 and EC 3.6.3.9.
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UniProtKB Entries (1)
| Q58K79 |
Q58K79_PIG
Sus scrofa
FXYD domain-containing ion transport regulator
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PDB Structure
| PDB | 4RES |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex.
Proc.Natl.Acad.Sci.USA
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