CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.2020 |
Domain Context
CATH Clusters
Superfamily | 3.40.50.2020 |
Functional Family | Hypoxanthine phosphoribosyltransferase |
Enzyme Information
2.4.2.8 |
Hypoxanthine phosphoribosyltransferase.
based on mapping to UniProt P00492
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- Guanine and 6-mercaptopurine can replace hypoxanthine.
|
UniProtKB Entries (1)
P00492 |
HPRT_HUMAN
Homo sapiens
Hypoxanthine-guanine phosphoribosyltransferase
|
PDB Structure
PDB | 4RAO |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents.
J.Med.Chem.
|