CATH Domain 4r7iA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P07333

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P07333

CSF1R_HUMAN

Homo sapiens

Macrophage colony-stimulating factor 1 receptor

PDB Structure

PDB	4R7I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. Tap, W.D., Wainberg, Z.A., Anthony, S.P., Ibrahim, P.N., Zhang, C., Healey, J.H., Chmielowski, B., Staddon, A.P., Cohn, A.L., Shapiro, G.I., Keedy, V.L., Singh, A.S., Puzanov, I., Kwak, E.L., Wagner, A.J., Von Hoff, D.D., Weiss, G.J., Ramanathan, R.K., Zhang, J., Habets, G., Zhang, Y., Burton, E.A., Visor, G., Sanftner, L., Severson, P., Nguyen, H., Kim, M.J., Marimuthu, A., Tsang, G., Shellooe, R., Gee, C., West, B.L., Hirth, P., Nolop, K., van de Rijn, M., Hsu, H.H., Peterfy, C., Lin, P.S., Tong-Starksen, S., Bollag, G. N Engl J Med