CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Aspartate-semialdehyde dehydrogenase |
Enzyme Information
| 1.2.1.11 |
Aspartate-semialdehyde dehydrogenase.
based on mapping to UniProt Q9KQG2
L-aspartate 4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH.
|
UniProtKB Entries (1)
| Q9KQG2 |
DHAS1_VIBCH
Vibrio cholerae O1 biovar El Tor str. N16961
Aspartate-semialdehyde dehydrogenase 1
|
PDB Structure
| PDB | 4R5M |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.
Acta Crystallogr.,Sect.D
|
