CATH Domain 4r4oA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.140	Nucleic acid-binding proteins

Domain Context

CATH Clusters

Superfamily	Nucleic acid-binding proteins
Functional Family	Replication protein A subunit

Enzyme Information

UniProtKB Entries (1)

RFA1_HUMAN

Homo sapiens

Replication protein A 70 kDa DNA-binding subunit

PDB Structure

PDB	4R4O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Diphenylpyrazoles as replication protein a inhibitors. Waterson, A.G., Kennedy, J.P., Patrone, J.D., Pelz, N.F., Feldkamp, M.D., Frank, A.O., Vangamudi, B., Souza-Fagundes, E.M., Rossanese, O.W., Chazin, W.J., Fesik, S.W. ACS Med Chem Lett