CATH Domain 4r0iA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Transmembrane serine protease 7

Enzyme Information

3.4.21.109

Matriptase.

based on mapping to UniProt Q9Y5Y6

Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.

-!- This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis. -!- Can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain form at an Arg residue to give active alpha- and beta-HGF, but it does not activate plasminogen, which shares high homology with HGF. -!- Can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade. -!- Belongs to peptidase family S1A.

UniProtKB Entries (1)

Q9Y5Y6

ST14_HUMAN

Homo sapiens

Suppressor of tumorigenicity 14 protein

PDB Structure

PDB	4R0I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach Goswami, R., Wohlfahrt, G., Mukherjee, S., Ghadiyaram, C., Nagaraj, J., Satyam, L.K., Subbarao, K., Gopinath, S., Krishnamurthy, N.R., Subramanya, H.S., Ramachandra, M. Bioorg.Med.Chem.Lett.