CATH Domain 4qzvA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Dipeptidyl peptidase 4

Enzyme Information

3.4.14.5

Dipeptidyl-peptidase IV.

based on mapping to UniProt P27487

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (2)

P27487	DPP4_HUMAN Homo sapiens Dipeptidyl peptidase 4
A3EX94	SPIKE_BCHK4 Tylonycteris bat coronavirus HKU4 Spike glycoprotein

PDB Structure

PDB	4QZV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26. Wang, Q.H., Qi, J.X., Yuan, Y., Xuan, Y., Han, P., Wan, Y., Ji, W., Li, Y., Wu, Y., Wang, J., Iwamoto, A., Woo, P.C., Yuen, K.Y., Yan, J., Lu, G.W., Gao, G.F. Cell Host Microbe