CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.880
Functional Family

Enzyme Information

4.2.1.130
D-lactate dehydratase.
based on mapping to UniProt Q10356
(R)-lactate = methylglyoxal + H(2)O.
-!- The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. -!- The other known route for this conversion is the two-step GSH- dependent pathway catalyzed by EC 4.4.1.5 and EC 3.1.2.6.

UniProtKB Entries (1)

Q10356
DJ1_SCHPO
Schizosaccharomyces pombe 972h-
Glutathione-independent glyoxalase DJ-1

PDB Structure

PDB 4QYT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Influence of peptide dipoles and hydrogen bonds on reactive cysteine pK(a) values in fission yeast DJ-1.
Madzelan, P., Labunska, T., Wilson, M.A.
Febs J.
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