CATH Domain 4qvxA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.437	Apoptosis Regulator Bcl-x
	1.10.437.10	Blc2-like

Domain Context

CATH Clusters

Superfamily	Blc2-like
Functional Family	Bcl-2-like protein 1

Enzyme Information

UniProtKB Entries (1)

B2CL1_HUMAN

Homo sapiens

Bcl-2-like protein 1

PDB Structure

PDB	4QVX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. Tao, Z.F., Hasvold, L., Wang, L., Wang, X., Petros, A.M., Park, C.H., Boghaert, E.R., Catron, N.D., Chen, J., Colman, P.M., Czabotar, P.E., Deshayes, K., Fairbrother, W.J., Flygare, J.A., Hymowitz, S.G., Jin, S., Judge, R.A., Koehler, M.F., Kovar, P.J., Lessene, G., Mitten, M.J., Ndubaku, C.O., Nimmer, P., Purkey, H.E., Oleksijew, A., Phillips, D.C., Sleebs, B.E., Smith, B.J., Smith, M.L., Tahir, S.K., Watson, K.G., Xiao, Y., Xue, J., Zhang, H., Zobel, K., Rosenberg, S.H., Tse, C., Leverson, J.D., Elmore, S.W., Souers, A.J. ACS MED.CHEM.LETT.