CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P52333
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P52333
JAK3_HUMAN
Homo sapiens
Tyrosine-protein kinase JAK3

PDB Structure

PDB 4QT1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Scaffold hopping towards potent and selective JAK3 inhibitors: discovery of novel C-5 substituted pyrrolopyrazines
De Vicente, J., Lemoine, R., Bartlett, M., Hermann, J.C., Hekmat-Nejad, M., Henningsen, R., Jin, S., Kuglstatter, A., Li, H., Lovey, A.J., Menke, J., Niu, L., Patel, V., Petersen, A., Setti, L., Shao, A., Tivitmahaisoon, P., Vu, M.D., Soth, M.
Bioorg.Med.Chem.Lett.