CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.210 |
Domain Context
CATH Clusters
| Superfamily | 3.20.20.210 |
| Functional Family | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase |
Enzyme Information
| 2.1.1.14 |
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
based on mapping to UniProt P82610
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.
-!- Requires phosphate. -!- The enzyme from Escherichia coli also requires a reducing system. -!- Unlike EC 2.1.1.13 this enzyme does not contain cobalamin.
|
UniProtKB Entries (1)
| P82610 |
METE_CANAL
Candida albicans SC5314
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
|
PDB Structure
| PDB | 4QQU |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The cobalamin-independent methionine synthase enzyme captured in a substrate-induced closed conformation.
J.Mol.Biol.
|
