CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | NADPH dehydrogenase 1 |
Enzyme Information
| 1.3.1.100 |
Chanoclavine-I aldehyde reductase.
based on mapping to UniProt Q4WZ70
Dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + NADPH.
-!- The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. -!- The enzyme catalyzes the reduction of chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde. -!- This hydrolyzes spontaneously to form 6,8-dimethyl-6,7- didehydroergoline, which is converted to festuclavine by EC 1.5.1.44.
|
UniProtKB Entries (1)
| Q4WZ70 |
EASA_ASPFU
Aspergillus fumigatus Af293
Chanoclavine-I aldehyde reductase easA
|
PDB Structure
| PDB | 4QNW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of an Aspergillus fumigatus old yellow enzyme (EasA) involved in ergot alkaloid biosynthesis.
Acta Crystallogr.,Sect.F
|
