CATH Domain 4qgnA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.10	Jelly Rolls

Domain Context

CATH Clusters

Superfamily	Jelly Rolls
Functional Family	1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Enzyme Information

1.13.11.54

Acireductone dioxygenase (Fe(2+)-requiring).

based on mapping to UniProt Q9BV57

1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2- oxobutanoate + formate.

-!- If Ni(2+) is bound instead of Fe(2+), the reaction catalyzed by EC 1.13.11.53 occurs instead. -!- The enzyme from Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC 8724 is involved in the methionine salvage pathway.

UniProtKB Entries (1)

Q9BV57

MTND_HUMAN

Homo sapiens

1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

PDB Structure

PDB	4QGN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Human acireductone dioxygenase with iron ion and L-methionine in active center Milaczewska, A.M., Chruszcz, M., Petkowski, J.J., Niedzialkowska, E., Minor, W., Borowski, T. TO BE PUBLISHED