CATH Domain 4q19A00

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Deoxycytidine kinase

2.7.1.74

Deoxycytidine kinase.

based on mapping to UniProt P27707

NTP + deoxycytidine = NDP + dCMP.

-!- Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.

DCK_HUMAN

Homo sapiens

Deoxycytidine kinase

PDB	4Q19
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. Nomme, J., Li, Z., Gipson, R.M., Wang, J., Armijo, A.L., Le, T., Poddar, S., Smith, T., Santarsiero, B.D., Nguyen, H.A., Czernin, J., Alexandrova, A.N., Jung, M.E., Radu, C.G., Lavie, A. J.Med.Chem.