CATH Domain 4pzfA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.43	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2
	3.30.43.10	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2

Domain Context

CATH Clusters

Superfamily	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2
Functional Family

Enzyme Information

1.21.3.3

Reticuline oxidase.

based on mapping to UniProt P30986

(S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2).

-!- Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)- tetrahydroprotoberberines. -!- The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants. -!- Formerly EC 1.5.3.9.

UniProtKB Entries (1)

P30986

RETO_ESCCA

Eschscholzia californica

Reticuline oxidase

PDB Structure

PDB	4PZF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction. Zafred, D., Steiner, B., Teufelberger, A.R., Hromic, A., Karplus, P.A., Schofield, C.J., Wallner, S., Macheroux, P. Febs J.