CATH Classification

Domain Context

CATH Clusters

Superfamily Endonuclease/exonuclease/phosphatase
Functional Family Tyrosyl-DNA phosphodiesterase 2

Enzyme Information

3.1.4.-
Phosphoric diester hydrolases.
based on mapping to UniProt Q9JJX7

UniProtKB Entries (1)

Q9JJX7
TYDP2_MOUSE
Mus musculus
Tyrosyl-DNA phosphodiesterase 2

PDB Structure

PDB 4PUQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2DNA and Top2RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2).
Gao, R., Schellenberg, M.J., Huang, S.Y., Abdelmalak, M., Marchand, C., Nitiss, K.C., Nitiss, J.L., Williams, R.S., Pommier, Y.
J.Biol.Chem.