CATH Domain 4pp7A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	RAF proto-oncogene serine/threonine-protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P15056

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P15056

BRAF_HUMAN

Homo sapiens

Serine/threonine-protein kinase B-raf

PDB Structure

PDB	4PP7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase. Wenglowsky, S., Ren, L., Grina, J., Hansen, J.D., Laird, E.R., Moreno, D., Dinkel, V., Gloor, S.L., Hastings, G., Rana, S., Rasor, K., Sturgis, H.L., Voegtli, W.C., Vigers, G., Willis, B., Mathieu, S., Rudolph, J. Bioorg.Med.Chem.Lett.