CATH Classification

Domain Context

CATH Clusters

Superfamily KEN domain
Functional Family Serine/threonine-protein kinase/endoribonuclease IRE1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9EQY0
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
3.1.26.-
Endoribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt Q9EQY0

UniProtKB Entries (1)

Q9EQY0
ERN1_MOUSE
Mus musculus
Serine/threonine-protein kinase/endoribonuclease IRE1

PDB Structure

PDB 4PL4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Sanches, M., Duffy, N.M., Talukdar, M., Thevakumaran, N., Chiovitti, D., Canny, M.D., Lee, K., Kurinov, I., Uehling, D., Al-Awar, R., Poda, G., Prakesch, M., Wilson, B., Tam, V., Schweitzer, C., Toro, A., Lucas, J.L., Vuga, D., Lehmann, L., Durocher, D., Zeng, Q., Patterson, J.B., Sicheri, F.
Nat Commun