CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.1440 | de novo design (two linked rop proteins) |
|
1.20.1440.180 | KEN domain |
Domain Context
CATH Clusters
| Superfamily | KEN domain |
| Functional Family | Serine/threonine-protein kinase/endoribonuclease IRE1 |
Enzyme Information
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9EQY0
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
| 3.1.26.- |
Endoribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt Q9EQY0
|
UniProtKB Entries (1)
| Q9EQY0 |
ERN1_MOUSE
Mus musculus
Serine/threonine-protein kinase/endoribonuclease IRE1
|
PDB Structure
| PDB | 4PL4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Nat Commun
|