CATH Domain 4pi3A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Cruzipain

Enzyme Information

3.4.22.51

Cruzipain.

based on mapping to UniProt P25779

Broad endopeptidase specificity similar to that of cathepsin L.

-!- Is located in the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P25779

CYSP_TRYCR

Trypanosoma cruzi

Cruzipain

PDB Structure

PDB	4PI3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. Jones, B.D., Tochowicz, A., Tang, Y., Cameron, M.D., McCall, L.I., Hirata, K., Siqueira-Neto, J.L., Reed, S.L., McKerrow, J.H., Roush, W.R. Acs Med.Chem.Lett.