CATH Domain 4pgfA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Adenosylhomocysteinase

Enzyme Information

3.3.1.1

Adenosylhomocysteinase.

based on mapping to UniProt P23526

S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.

-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

P23526

SAHH_HUMAN

Homo sapiens

Adenosylhomocysteinase

PDB Structure

PDB	4PGF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation. Wang, Y., Kavran, J.M., Chen, Z., Karukurichi, K.R., Leahy, D.J., Cole, P.A. J.Biol.Chem.