CATH Domain 4p8oA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.565	Heat Shock Protein 90
	3.30.565.10	Histidine kinase-like ATPase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Histidine kinase-like ATPase, C-terminal domain
Functional Family

Enzyme Information

5.6.2.3

DNA topoisomerase (ATP-hydrolyzing).

based on mapping to UniProt Q6GKU0

ATP-dependent breakage, passage and rejoining of double-stranded DNA.

-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

Q6GKU0

GYRB_STAAR

Staphylococcus aureus subsp. aureus MRSA252

DNA gyrase subunit B

PDB Structure

PDB	4P8O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability. Grillot, A.L., Tiran, A.L., Shannon, D., Krueger, E., Liao, Y., O'Dowd, H., Tang, Q., Ronkin, S., Wang, T., Waal, N., Li, P., Lauffer, D., Sizensky, E., Tanoury, J., Perola, E., Grossman, T.H., Doyle, T., Hanzelka, B., Jones, S., Dixit, V., Ewing, N., Liao, S., Boucher, B., Jacobs, M., Bennani, Y., Charifson, P.S. J.Med.Chem.