CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase |
Enzyme Information
| 2.3.1.245 |
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase.
based on mapping to UniProt P76143
Glycerone phosphate + acetyl-CoA = 3-hydroxy-5-phosphonooxypentane-2,4- dione + coenzyme A.
-!- The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.
|
UniProtKB Entries (1)
| P76143 |
LSRF_ECOLI
Escherichia coli K-12
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
|
PDB Structure
| PDB | 4P2V |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2.
Proc.Natl.Acad.Sci.USA
|