CATH Classification

Domain Context

CATH Clusters

Superfamily Zn peptidases
Functional Family Carboxypeptidase B2

Enzyme Information

3.4.17.20
Carboxypeptidase U.
based on mapping to UniProt Q96IY4
Release of C-terminal Arg and Lys from a polypeptide.
-!- Pro-carboxypeptidase U in plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U. -!- Activity similar to that of the more stable lysine carboxypeptidase, except no preference is shown for Lys over Arg. -!- Belongs to peptidase family M14.

UniProtKB Entries (1)

Q96IY4
CBPB2_HUMAN
Homo sapiens
Carboxypeptidase B2

PDB Structure

PDB 4P10
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa).
Brink, M., Dahlen, A., Olsson, T., Polla, M., Svensson, T.
Bioorg.Med.Chem.