CATH Domain 4oz2A02

Superfamily	Nucleotide cyclase
Functional Family	Adenylate cyclase type 10

4.6.1.1

Adenylate cyclase.

based on mapping to UniProt Q96PN6

ATP = 3',5'-cyclic AMP + diphosphate.

-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

ADCYA_HUMAN

Homo sapiens

Adenylate cyclase type 10

PDB	4OZ2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Saalau-Bethell, S.M., Berdini, V., Cleasby, A., Congreve, M., Coyle, J.E., Lock, V., Murray, C.W., O'Brien, M.A., Rich, S.J., Sambrook, T., Vinkovic, M., Yon, J.R., Jhoti, H. Chemmedchem