CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

4.2.3.146
Cyclooctat-9-en-7-ol synthase.
based on mapping to UniProt C9K1X5
Geranylgeranyl diphosphate + H(2)O = cyclooctat-9-en-7-ol + diphosphate.
-!- Isolated from the bacterium Streptomyces melanosporofaciens, where it is part of the biosynthesis of cyclooctatin, a potent inhibitor of lysophospholipase.

UniProtKB Entries (1)

C9K1X5
COTB2_STRMJ
Streptomyces melanosporofaciens
Cyclooctat-9-en-7-ol synthase

PDB Structure

PDB 4OMH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The first structure of a bacterial diterpene cyclase: CotB2.
Janke, R., Gorner, C., Hirte, M., Bruck, T., Loll, B.
Acta Crystallogr.,Sect.D