CATH Domain 4ol9A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	2-dehydropantoate 2-reductase

Enzyme Information

1.1.1.169

2-dehydropantoate 2-reductase.

based on mapping to UniProt P9WIL1

(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH.

UniProtKB Entries (1)

PANE_MYCTU

Mycobacterium tuberculosis H37Rv

Putative 2-dehydropantoate 2-reductase

PDB Structure

PDB	4OL9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of putative 2-dehydropantoate 2-reductase PanE from Mycobacterium tuberculosis complexed with NADP and oxamate Dranow, D.M., Wernimont, A.K., Abendroth, A., Pierce, P.G., Bullen, J., Edwards, T.E., Lorimer, D., Seattle Structural Genomics Center for Infectious Disease To be Published