CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.10 | HIV Type 1 Reverse Transcriptase; Chain A, domain 1 |
|
3.10.10.10 | HIV Type 1 Reverse Transcriptase, subunit A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | HIV Type 1 Reverse Transcriptase, subunit A, domain 1 |
| Functional Family |
Enzyme Information
| 2.7.7.49 |
RNA-directed DNA polymerase.
based on mapping to UniProt Q99315
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
|
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt Q99315
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
| 3.1.26.4 |
Ribonuclease H.
based on mapping to UniProt Q99315
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
|
| 3.4.23.- |
Aspartic endopeptidases.
based on mapping to UniProt Q99315
|
UniProtKB Entries (1)
| Q99315 |
YG31B_YEAST
Saccharomyces cerevisiae S288C
Transposon Ty3-G Gag-Pol polyprotein
|
PDB Structure
| PDB | 4OL8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry.
Nat.Struct.Mol.Biol.
|
