CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.1360 | Gyrase A; domain 2 |
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3.30.1360.10 | RNA polymerase, RBP11-like subunit |
Domain Context
CATH Clusters
Superfamily | RNA polymerase, RBP11-like subunit |
Functional Family | DNA-directed RNA polymerase subunit alpha |
Enzyme Information
2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt Q5SHR6
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
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UniProtKB Entries (1)
Q5SHR6 |
RPOA_THET8
Thermus thermophilus HB8
DNA-directed RNA polymerase subunit alpha
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PDB Structure
PDB | 4OIR |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife
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